The biochemistry of apoptosis
Article Abstract:
The biochemistry of apoptosis, the regulated destruction of a cell, is discussed.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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Interaction between the C. elegans cell-death regulators CED-9 and CED-4
Article Abstract:
A study shows the presence of physical interaction between CED-9 and CED-4. This interaction may be essential for CED-9 function because mutations that lessen or remove CED-9 activity also disrupt its ability to bind CED-4. These findings suggest that CED-9 may control Caenorhabditis elegans cell death by binding to and regulating CED-4 activity. In mammalian Bcl-2 family members, apoptosis may be controlled by interaction and regulation of CED-4 homologues or analogues.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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Death cycle and Swiss army knives
Article Abstract:
It has been established that the cell-death suppressor Bcl-2 can protect cells downstream of cytochrome c release. This finding forces a reassessment of the view that Bcl-2 and Bcl-xL, also a cell-death suppressor, act upstream of cytochrome c in the pathway to cell death. The research involved microinjecting high concentrations of cytochrome c into the cytosol. It was found that high levels of Bcl-2 block most of the deaths, suggesting that Bcl-2 can function downstream of cytochrome c.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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