Lgl, pins and aPKC regulate neuroblast self-renewal versus differentiation
Article Abstract:
A study is conducted to test whether cell polarity genes, known to regulate embryonic neuroblast asymmetric cell division, and also to regulate neuroblast self-renewal. The results show that the lgl pins neuroblast show ectopic cortical localization of atypical protein kinase C (aPKC), and a decrease in aPKC expression reduces neuroblast number, suggesting that aPKC promotes neuroblast self-renewal.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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Regulation of neuroblast competence in Drosophila
Article Abstract:
Neural progenitors, which generate different cell types in reproducible order in the retina, cerebral cortex and in the spinal cord are described. It is however unknown, how neural progenitors change over time to generate different cell types.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
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From embryo to axon
Article Abstract:
A number of cell types in the human body, varying from the epithelial cells lining the lungs and skin to neurons, have to be polarized in order to operate properly. The same mechanism might determine the polarity of several of these cells.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
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