Malarial haemozoin/beta-haematin supports haem polymerization in the absence of protein
Article Abstract:
A study of the lability of haem polymerase activity shows that polymerization is a chemical process mediated by haemozoin and beta-haematin. These results challenge the enzyme-mediation of the process and its dependence on protein. Chloroquine inhibits the activity of beta-haematin. Experimental studies reveal that both trophozoite lysate and acetonitrile extracts from synthetic beta-haematin support haem polymerization.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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Aminoglycoside antibiotics induce bacterial biofilm formation
Article Abstract:
Demonstrations show that subinhibitory concentrations of aminoglycoside antibiotics induce biofilm formation in Pseudomonas aeruginosa and Escherichia coli. Results suggest that biofilm formation can be a specific, defensive reaction to the presence of antibiotics, and the molecular basis of this response includes alterations in the level of cyclic di-guanosine monophosphate.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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