Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are mutually exclusive
Article Abstract:
The enzyme arginine methylatransferase PRMT6 which catalyses histone H3 arginine 2 (H3R2me2a) was identified to characterize the relationship between H3 lysine 4 (H3K4me3) and H3R2me2a. The findings suggest that mutual antagonism between H3R2 and H3K4 methylation together with MLL-family complexes contribute to the localized patterns of H3H4 tri-methylation of transcriptionally active promoters in mammalian genomes.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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Protein-based peptide-bond formation by aminoacyl-tRNA protein transferase
Article Abstract:
The crystal structure analysis of the Escherichia coli Eubacterial leucyl/phenylalanyl-tRNA protein transferase (LF-transferase) complex with phenyalanyl adenosine (rA-Phe) is described. The protein-based mechanism for peptide-bond formation by LF-transferase was found to be similar to the reverse reaction of the acylation step observed in the peptide hydrolysis reaction by serine proteases.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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ClpS is an essential component of the N-end rule pathway in Escherichia coli
Article Abstract:
Study is conducted to show that ClpAP-specific adaptor, ClpS, is essential for degradation of N-end rule substrates by ClpAP in bacteria. Through interaction with this signal, ClpS converts the ClpAP machine into a protease with exquisitely defined specificity, ideally suited to regulatory proteolysis.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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