Molecular recycling within amyloid fibrils
Article Abstract:
The nature of the amyloid structure is probed by monitoring hydrogen/deuterium exchange in fibril formed from an SH3 domain using a combination of nuclear magnetic resonance spectroscopy and electrospray ionization mass spectrometry. The results reveal that under the conditions used in the study, exchange is dominated by a mechanism of dissociation and re-association that results in the recycling of molecules within the fibrils population.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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Intrinsic dynamics of an enzyme underlies catalysis
Article Abstract:
The intrinsic plasticity and enzymatic plasticity of the protein is a key characteristic of catalysis. The dynamics of the prolyl cis-trans isomerase cyclophilin A (CypA) in its substrate-free state and during catalysis were catalysis is characterized with NMR relaxation experiments.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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Low-populated folding intermediates of Fyn SH3 characterized by relaxation dispersion NMR
Article Abstract:
The relaxation dispersion nuclear magnetic resonance (NMR) spectroscopy is used to identify, for two mutational variants of a protein, the SH3 domain from Fyn tyrosine kinase, a low-population folding intermediate in equilibrium with its unfolded and fully folded states.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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