Monocular deprivation induces homosynaptic long-term depression in visual cortex
Article Abstract:
Monocular deprivation during early postnatal development can result in depression of synaptic transmissions. The Bienenstock-Cooper-Munro (BCM) theory proposes that homosynaptic mechanism account for deprivation effects. The consequences of brief monocular deprivation by lid suture were compared with monocular inactivation through intra-ocular treatment with tetrodotoxin. The results show that greater depression of deprived-eye responses in kitten visual cortex is caused by monocular lid suture, than treatment with tetrodotoxin.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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NT-4-mediated rescue of lateral geniculate neurons from effects of monocular deprivation
Article Abstract:
The TrkB ligand NT-4, a neurotrophin, protects the lateral geniculate neurons (LGN) from the dystrophic influence of monocular deprivation (MD). LGN competes for binding NT-4. MD shrinks the neurons in the closed-eye layer of the LGN but neurons with neurotrophin-coated microspheres are protected from atrophy. The fact that the other TrkB ligand brain-derived neurotrophic factor (BDNF) cannot protect the neurons from MD proves that NT-4 and BDNF play different roles in neural development.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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Disruption of orientation tuning in visual cortex by artificially correlated neuronal activity
Article Abstract:
Neuronal cells adapt orientation preference in relation to the electrical activity which proved to be resilient despite changes in the activity patterns after their initial formation. Cortical neurons display physiological specificity as revealed by the orientation maps which remained undisturbed despite the changes in activity of on and off inputs to the visual cortex during developmental period when orientation tuning and map formation occurs.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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