Movement of motor and cargo along cilia
Article Abstract:
Fluorescence microscopy has been used to visualize for the first time the intracellular transport of a motor and its cargo in vivo. An investigation of the anterograde movement of green fluorescent protein-labelled kinesin-II motors and intraflagellar transport (IFT) rafts within sensory cilia on chemosensory neurons in living Caenorhabditis elegans provides strong evidence that heterotrimeric kinesin-II is the motor protein that drives anterograde IFT. This work should make it possible to directly observe motor and cargo molecules taking part in IFT in a wide range of cilia and flagella.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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Functional coordination of intraflagellar transport motors
Article Abstract:
Three genes whose protein products mediate the functional coordination of the intraflagellar transport (IFT) motors are identified by observing the movement of fluorescent IFT motors and IFT particles along the cilia of numerous ciliary mutants. IFT motors assemble and maintain cilia by transporting ciliary precursors, bound to protein complexes called IFT particles, from the base of the cilium to their site of incorporation at the distal tip.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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Force-velocity relationships in kinesin-driven motility
Article Abstract:
Force-velocity curves obtained with the use of a centrifuge microscope show the maximal isometric force generated per kinesin in kinesin-driven motility is 0.12+ or -0.03 pN per molecule. A detailed explanation of the methodology used to arrive at this figure is included.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
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