Myoblast transferred to the limbs of embryos are committed to specific fibre fates
Article Abstract:
The role of myoblast commitment in fibre type specification during embryonic development was investigated. Myoblasts of specific types from embryonic and adult muscles were cloned, transfected with a reporter gene and transferred into developing limb buds. Fibre formation patterns in the limb resembled that of myosin heavy chain gene expression in cell culture. The findings show that the commitment of distinct myoblast types to the formation of specific fibre types lead to skeletal muscle type diversity during avian limb development.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
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All limbs are not the same
Article Abstract:
Published papers have recently assumed that limb development in all vertebrates is the same. However an examination of the expression of eight signalling and regulatory molecules in Xenopus limb development finds that the assumption is incorrect. Proximodistal and anteroposterior systems in Xenopus appear similar to amniote species, although the dorsoventral systems seems to be different.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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Neu tack on neuregulin
Article Abstract:
Research on embryonic development and cell-cell signalling, with particular emphasis on neuregulin growth factors, has been conducted using mice as test subjects. Neuregulins are a big group of growth factors that are both attached to a memberane and secreted. Its receptors are known as erB2 or neu, erB3 and erB4 and experiment results indicate their varied interaction with neuregulins.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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