Neisseria PilC protein identified as type-4 pilus tip-located adhesin

Article Abstract:

The PilC protein, a variable of the principal pilus subunit (Pil) of the Neisseria meningitidis and Neisseria gonorrhoeae is isolated from the gonococcal strains. The isolated proteins exhibit specific interaction with epithelial cells of humans. The pilus-mediated affinity of the PilC binding is involved in the attachment process of Neissera gonorrheae and Neisseria meningitidis. The attachment process involves the reaction of the two types of pathogens with epithelial cell receptors.

Adhesion, Adhesion (Surface chemistry)

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TPL-2 kinase regulates the proteolysis of the NF-kappaB-inhibitory protein NF-kappaB1 p105

Article Abstract:

NF-kappaB transcription factor consists of homodimeric and heterodimeric compounds of Rel/NF-kappaB-family polypeptides. NF-kappaB1 encodes p105, a precursor protein, from which p50 is produced. P105 also operates as an NFkappaB-inhibitory protein. It is shown that TPL-2 forms a complex with the p105 carboxy-terminus. TPL-2 expression leads to phosphorylation and further degradation of p105, although p50 production is maintained.

Polypeptides, Proteolysis

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Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein

Article Abstract:

Mice having a targeted mutation in the PSD-95 gene were characterized to reveal the function of PSD-95 in the brain. PSD-95 was found to be significant in signal transduction. There was dramatic alterations to NMDA-receptor-mediated synaptic plasticity, and impaired learning, giving support to the predictions of the dependence of neural-network models on bidirectional synaptic plasticity, in learning and memory mediation.

United States, Mice, mutant strains, Mutant mice, Neuroplasticity

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