Netrins find their receptors
Article Abstract:
Netrin-1 and netrin-2 are phylogenetically conserved molecular factors related to the unc-6 gene that guide the migrating nerve axons to their targets during development. The ventral-to-dorsal gradient of netrin protein is due to a repulsive or an attractive guidance cue, which depends on the receptor composition. Chemoattractants guide the migrating axons to their destinations. Mutations to the unc-6, unc-5 and unc-40 genes perturb the dorsoventral migration of pioneer axons and cells.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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Regeneration of adult axons in white matter tracts of the central nervous system
Article Abstract:
Adult central nervous system (CNS) white matter was investigated to determine whether it can support long-distance regeneration of adult axons in the absence of glial scarring. A microtransplantation technique to minimize scarring was used to inject dissociated adult rat dorsal root ganglia directly int adult rate CNS pathways. The results show that reactive glial extracellular matrix at the lesion site is directly linked to failure of axon regrowth in vivo.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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In vivo regulation of axon extension and pathfinding by growth-cone calcium transients
Article Abstract:
It is reported that growth cones generate transient elevations of (Ca(super2+))i during migration within the embryonic spinal cord. Photorelease of a Ca(super2+) chelator was found to accelerate axon extension. Growth-cone stalling and axon retraction were found to be linked to high frequencies of Ca(super2+) transients, suggesting that axon growth is regulated by growth-cone Ca(super2+) transients.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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