Nodal antagonists regulate formation of the anteroposterior axis of the mouse embryo
Article Abstract:
For the normal migration of the distal visceral endoderm (DVE), nodal signaling and the regionalization of its antagonists, is required. However the first overt manifestation of the body plan in the mouse, is the foundation of the anteroposterior (A-P) axis.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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Functional genetic analysis of mouse chromosome 11
Article Abstract:
Biologists need systematic approaches to determine the function of each gene now that the mouse and human genome sequences are complete. Determining the consequence of mutations in living organisms is a powerful way to discover gene function.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
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Mismatch repair genes identified using genetic screens in Blm-deficient embryonic stem cells
Article Abstract:
Phenotype-driven recessive genetic screens in diploid organisms require a strategy to render the mutation homozygous. The combination of insertional mutagenesis in Blm-deficient cells establishes a new approach for these genetic screens.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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- Abstracts: Haemangioblast commitment is initiated in the primitive streak of the mouse embryo. cdx4 mutants fail to specify blood progenitors and can be rescued by multiple hox genes
- Abstracts: Regulatory constraints in the evolution of the tetrapod limb anterior-posterior polarity. A uniquely specialized ear in a very early tetrapod