Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1
Article Abstract:
It has been established that the transcriptional coactivator PGC-1 is induced by cyclic AMP and glucocorticoids in isolated hepatocytes. During fasting and other times of relative insulin deficiency, it is strongly induced in the liver.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
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Insulin-regulated hepatic gluconeogenesis through FOX01-PGC-1alpha interaction
Article Abstract:
Results show that the forkhead transcription factor FOXO1 and the peroxisome proliferative activated receptor-gamma co-activatior 1 (PGC-1alpha) interact and catalyze the insulin-regulated gluconeogenesis. Data indicate that PGC-1alpha binds and co-activates FOXO1 and that insulin suppresses gluconeogenesis, which is simulated by PGC-1alpha.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
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Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1
Article Abstract:
The Sir2 homologue, SRT1, controls the gluconeogenic/glycolytic pathways in liver in response to fasting signals through the transcriptional coactivator PGC-1alpha. A molecular mechanism is identified whereby SIRT1 functions in glucose homeostasis as a modulator of PGC-1alpha.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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