Ornithine decarboxylase activity is critical for cell transformation
Article Abstract:
Ornithine decarboxylase (ODC), an enzyme, causes cells to develop into new forms and to grow even to the point of becoming malignant. The accelerated cellular transformation and proliferation that followed the experimental transfection of NIH3T3 cells with ODC confirmed this enzyme's carcinogenic effect. Furthermore, the finding that the transformation stops when ODC's stimulation is canceled out provided additional evidence of the enzyme's role in malignancy. The ODC gene can thus be added to the list of cellular proto-oncogenes.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
User Contributions:
Comment about this article or add new information about this topic:
Chromosomal instability
Article Abstract:
High linear energy transfer (LET) radiation from alpha particles produces chromosomal instability in murine haematopoietic stem cells. However, the chromosomal instability produced by LET radiation is characterized by the appearance of dicentrics or nontransmissible chromosomal rearrangements. The rearrangements do not turn up randomly but at certain telomeric regions. These biological effects may account for the role of LET radiation in cell transformation and carcinogenesis.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
User Contributions:
Comment about this article or add new information about this topic:
Expression of Hox-7.1 in myoblasts inhibits terminal differentiation and induces cell transformation
Article Abstract:
Hox-7.1, a homeobox-containing gene, prevents myoblasts and myogenic cells from developing normally. Furthermore, Hox-7.1's ability to initiate the abnormal growth of cells indicates that it is an oncogene or tumor-producing gene. Hox-7.1's effects were determined by transfecting myoblasts with some of its complementary DNA. However, the closely related Hox-8.1 gene did not affect cell differentiation and proliferation in this way.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Bringing two hearts together. Repressor activity of headless/Tcf3 is essential for vertebrate head formation. Unexpectedly similar rates of nucleotide substitution found in male and female hominids
- Abstracts: Immunological activity of covalently linked T-cell epitopes. Life-or-death decisions
- Abstracts: Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction. An alternative to destruction
- Abstracts: Increased herbivory in forest isolates: implications for plant community structure and composition. Vascular plant diversity as a surrogate for bryophyte and lichen diversity
- Abstracts: Linkage of a nasopharyngeal carcinoma susceptibility locus to the HLA region. Molecular mimicry in liver disease