PKC-theta is required for TCR-induced NF-kappa-B activation in mature but not immature T lymphocytes

Article Abstract:

Protein kinase C (PKC)-theta, one of several PKC isoenzymes expressed in T cells, is vital for T-cell antigen receptor (TCR)-mediated T-cell activation. However, it is not required during TCR-dependent thymocyte development. The activation of NF-kappa-B by TCR triggering involves a PKC-theta-dependent upstream signalling pathway that leads to the degradation of I-kappa-B-alpha but is separate from pathways used by TNF and IL-1 receptor family members. It must still be established whether the distinct pathways converge in the activation of elements of the I-kappa-B kinase complex.

Lymphocyte transformation

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Identification of a major co-receptor for primary isolates of HIV-1

Article Abstract:

The CC-CRK-5 beta-chemokine receptor functions as a co-receptor for the primary macrophage-trophic strains of the human immunodeficiency virus 1 (HIV-1) and acts along with CD4 to enable the entry of the virus into host cells. Cells co-expressing CD4 and CC-CRK-5 are highly susceptible to HIV infection while those co-expressing CD4 and other members of the CC-CRK-5 family are resistant to infection. CC-CRK-5 activates the fusion of plasma membrane with the HIV-1 envelope. Beta-chemokines are cytokines that suppress HIV infection by blocking its entry and replication in cells.

Analysis, HIV infection, HIV infections, HIV (Viruses), HIV, Cytokines, Virus receptors

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Selective modulation of protein kinase C-theta during T-cell activation

Article Abstract:

Immunofluorescence microscopy studies suggest that protein kinase C-theta (PKC) plays an important role in T-cell activation. Of six isoforms of protein kinase C in antigen-presenting cell activation (APC) studies, only PKC-theta exhibited selective antigen-dependent translocation to the cell contact. In vitro kinase activity assays of PKC immunoprecipitates from T-cell and APC conjugates showed a selective increase in the activity of PKC-theta indicating that the translocated enzyme is active.

T cells

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