PTK7/CCK-4 is a novel regulator of planar cell polarity in vertebrates
Article Abstract:
A study reveals that mutation in the mouse protein tyrosine kinase 7 (PTK7) gene, which encodes an evolutionarily conserved transmembrane protein with tyrosine kinase homology, disrupts neural tube closure and stereociliary bundle orientation, and shows genetic interactions with a mutation in the mouse Van Gogh homologue vangl2. It is also indicated that PTK7 is a novel regulator of PCP in vertebrates.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene
Article Abstract:
The Deleted in colorectal cancer (DCC) gene was identified as a potential tumour-suppressor gene on human chromosome 18q, although it has not been conclusively implicated as the colorectal tumour-suppressor gene. Investigations indicate that DCC is an axonal chemoattractant netrin-1 receptor. The effects of inactivation of the mouse homologue of DCC are similar to those in netrin-1-deficient mice.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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Class 3 semaphorins control vascular morphonogenesis by inhibiting integrin function
Article Abstract:
The autocrine loops of SEMA3 chemorepellents exert an essential permissive role in the execution of the complex morphogenetic process. This is possible by inhibiting integrin-mediated adhesion of endothelial cells (ECs) to the extracellular matrix (ECM), by allowing deadhesion necessary for the vascular remodeling.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
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