Post-transcriptional transactivation of human retroviral envelope glycoprotein expression by herpes simplex virus Us11 protein
Article Abstract:
Herpes simplex virus type 1 (HSV-1) Us11 protein, a gene product that is found within the virion, enters cells after infection, shows a nucleocytoplasmic localization at early times, and then piles up in the nucleoli. This ribonucleic acid-binding basic phosphoprotein is believed to be a part of post-transcriptional regulation of gene expression following HSV-1 infection. Elements responsive to Rex and Rev, proteins that are vital in the cytoplasmic expression of unspliced gag-pol and singly spiced env transcripts, can be bound by HSV-1 Us11 protein.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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Retroviral invasion of the koala genome
Article Abstract:
Studies show that koala retrovirus (KoRV), a functional virus associated with neoplasia, also shows features of an inserted endogenous retrovirus that is vertically transmitted. The findings that some isolated koala populations have not incorporated KoRV into their genomes, combined with its high activity and variability, suggests that KoRV is a virus in transition between an exogenous and endogenous element, providing a model for studying the evolutionary event of a retrovirus invading a mammalian genome.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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Bacterial and retroviral superantigens share a common binding region on class II MHC antigens
Article Abstract:
Synthetic peptides are used to detect a site on the mouse mammary tumour virus (MMTV)-1 superantigen that binds to class II major histocompatibility complex (MHC) antigens, which is surrounded by amino-acid residues 76-119 of the MMTV-1 superantigens. Experiments involving direct binding and competition reveal that the MMTV superantigen and Staphylococcal enterotoxin A (SEA) bind to atleast one common region on class II-MHC antigens.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
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