A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis
Article Abstract:
It is possible to use a cDNA subtraction strategy to isolate cDNAs encoding a functional cell-surface receptor. Exposure to leukotriene B4 produces a strong chemotactic response and activation of intracellular signalling in CHO cells expressing the receptor. These results indicate that a single signalling molecule can bind to both cell-surface and intracellular receptors. This research could have significance for investigations into the onset and progress of a range of inflammatory diseases.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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Common mechanism of infection by lentiviruses
Article Abstract:
A study was conducted on the common mechanism of infection by the primate and feline lentiviruses. The results indicate that cell-culture-adapted strains of feline immunodeficiency virus (FIV) use the CXC chemokine receptor CXCR4 to infect and fuse with human cells. There is evidence to suggest that the chemokine receptor may be a common link between FIV and primate lentiviruses and a key factor in the pathogenesis of AIDS.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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Comment about this article or add new information about this topic: