Quantal transmitter secretion from myocytes loaded with acetylcholine
Article Abstract:
The deposit of acetylcholine (A Ch) on an isolated Xenopus myocyte causes A Ch to be released quantally, resulting in the stimulation of the myocyte's surface A Ch channels and the initiation of membrane currents similar to miniature endplate currents. Quantal transmitter secretion seems not to require pathways of secretion that are unique to neurons. Further, presynaptic differentiation may depend primarily on the supply of transmitter and modification of the secretion pathway that already exists.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
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Spike-timing-dependant synaptic plasticity depends on dendritic location
Article Abstract:
A study reports that both the magnitude and the temporal specificity of spike-timing-dependent synaptic modification vary along the apical dendrite of rat cortical layer 2/3 pyramidal neurons. Computer simulation studies showed that the dendritic inhomogeneity of spike-timing-dependant synaptic modification leads to differential input selection at distal and proximal dendrites according to the temporal characteristics of presynaptic spike trains.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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Acetylcholine revisited
Article Abstract:
A lesion-induced injury in an animal can be recovered by transplanting fibroblasts which act on the host neocortex by secreting acetylcholine (ACh) which recovers impaired cortical cholinergic function. The ACh is an effective neurotransmitter to promote recovery of the denervated cortex of the model nucleus basalis magnocellularis lesioned rats. It helps to maintain the normal cognitive function of the brain.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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