Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein I(kappa)B(zeta)
Article Abstract:
Studies reveal that I(kappa)B(zeta) is indispensable for the expression of a subset of genes activated in Toll-like receptors (TLR)/Interleukin (IL)-1R signaling pathways where I(kappa)B(zeta)-deficient cells show severe impairment of IL-6 production. The fact that I(kappa)B(zeta) is an inducible protein, TLR/IL-1R mediated IL-6 expression may be regulated in a two-step mechanism.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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Regulated degradation of a class V myosin receptor directs movement of the yeast vacuole
Article Abstract:
Biochemists have discovered a mechanism in yeast cells that regulates the position of organelles within the cell. Analysis of this mechanism reveals a transport complex that can be assembled or disassembled to ensure the vacuole reaches the proper destination.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
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Mutation of F1G4 causes neurodegeneration in the pale tremor mouse and patients with CMT4J
Article Abstract:
The studies related to a multi-organ disorder with neuronal degeneration in the central nervous system identified pathogenic mutation of human F1G4 on chromosome 6q21 as hereditary motor and sensory neuropathy.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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