Regulation of calcium signalling in T lymphocytes by the second messenger cyclic ADP-ribose
Article Abstract:
There is evidence that cyclic ADP-ribose (cADPR) is vital for long-term Ca2+ entry, which is significant for the generation of a functional immune response as T cells need the sustained Ca2+ signal for clonal expansion. It seems that cADPR has a direct modulatory impact on channel opening. The stimulatory effect of cADPR on the binding velocity of ryanodine is dose dependent and specific. This effect is reversed by various agonists of ryanodine receptor and of cADPR.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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InsP4 facilitates store-operated calcium influx by inhibition of InsP3 5-phosphatase
Article Abstract:
A new study investigates the function of inositol 1,3,4,5-tetrakisphosphate (InsP4) in calcium influx in the mast cell line RBL-2H3. It is shown that it InsP4 inhibits metabolism of inositol 1,4,5-trisphosphate (InsP3) through InsP3 5-phosphatase.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology
Article Abstract:
Research examining the process of gating of free ADP-ribose intracellular signalling molecules of vertebrates is presented. Particular attention is given to the detection of native LTRPC2 functions in monocite cell lines such as U937.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
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