The language of covalent histone modifications
Article Abstract:
The large network of post-translational modifications that decorates histone tails seems to be a mechanism for differential regulation of chromatin activity in a number of separate biological settings. Research in this area has focused on a short stretch of core histone H3, but many of the findings will probably apply to all of the histone termini. It is suggested that distinct histone modifications, on one or more tails, function sequentially or in combination to create a histone code to which other proteins refer to instigate distinct downstream events.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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Regulation of chromatin structure by site-specific histone H3 methyltransferases
Article Abstract:
Research is presented concerning the influences on chromosome function of the organization of higher-order structures of chromatin. The nucleation of higher-order chromatin by histone tails is discussed.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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Binary switches and modification cassettes in histone biology and beyond
Article Abstract:
An immense number of post-translational modifications on histone proteins are described. Binary switches and modification cassettes are introduced in histone biology, which might govern the biological readout of distinct modification patterns.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
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