Relaxation of insulin-like growth factor II gene imprinting implicated in Wilms' tumour
Article Abstract:
The role of genomic imprinting in the development of embryonal tumors was investigated. Imprinted genes are implicated in the development in mice of Wilms' tumor and Beckman-Wiedemann syndrome, but the exact underlying mechanism is not well understood. The study protocol involved the study of the expression of insulin-like growth factor II (IGF2) gene which is highly expressed in Wilms' tumors. The results showed that IGF2 is expressed in fetal tissues from the paternal allelle, but is expressed biallelically in Wilms' tumor. This indicates that relaxation of imprinting could be one mechanism in carcinogenesis.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
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Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura
Article Abstract:
Research describing the genetic basis of the systemic illness thrombotic thrombocytopenic purpura is presented. In particular the role of the ADAMTS13 gene is investigated.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
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To clot or not
Article Abstract:
Issues concerning the mechanism of blood clotting in multicellular animals are discussed. In particular the role of the von Willbrand factor protein is examined.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
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