Repeated cocaine exposure in vivo facilitates LTP induction in midbrain dopamine neurons
Article Abstract:
A report that following repeated exposure to cocaine in vivo, excitatory synapses to rat ventral tegmental area (VTA) dopamine neurons become highly susceptible to the induction of long-term potentiation (LTP) by correlated pre- and postsynaptic activity is presented. This facilitated LTP induction is caused by cocaine-induced reduction of GABA(sub A) receptor-mediated inhibition of these dopamine neurons.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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Distributed synaptic modification in neural networks induced by patterned stimulation
Article Abstract:
Paired-pulse stimulation of one neuron carried out repeatedly for short periods causes specific polysynaptic pathways to be weakened or reinforced in a way which is dependent on the interpulse interval. Temporal information can be stored as spatially distributed patterns of synaptic adaptations in a neural network.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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- Abstracts: GTP-dependent twisting of dynamin implicates constriction and tension in membrane fission. Dual-key strategy
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