Repression of RNA polymerase III transcription by the retinoblastoma protein
Article Abstract:
The retinoblastoma tumor-suppressor protein (Rb) inhibits RNA polymerase (pol) III transcription and the suppression of protein biosynthesis is probably necessary for tumor suppression. Mutations in the Rb pocket region, similar to those that occur in tumors and are caused by viral transforming proteins that inactivate Rb, remove the block on pol III transcription. An intact pocket region is also necessary for E2F binding and repression, and growth inhibition by Rb.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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Protective packaging for DNA
Article Abstract:
The authors have investigated histone proteins known for their structural role in packaging DNA into a compact form. They report that these proteins can also work as tumor suppressors preventing cancer development.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
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A role for Saccharomyces cerevisiae histone H2A in DNA repair
Article Abstract:
A conserved motif has been characterized in the carboxy terminus of the core histone H2A from Saccharomyces cerevisiae.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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- Abstracts: Leptin regulation of bone resorption by the sympathetic nervous system and CART. The complexities of skeletal biology
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