Requirement of 19K form of Sonic hedgehog for induction of distinct ventral cell types in CNS explants
Article Abstract:
A vertebrate from the hedgehog family known as the Sonic hedgehog (Shh) is processed to generate the peptides Mr 19K and 26/27K. In vitro experiments conducted on various vertebrate embryos and neural explants show that Shh is capable of mediating floor-plate induction. Recombinant Shh peptides are applied to neural explants in serum-free conditions. Shh is proposed to display morphogenic qualities to induce different ventral cell types in the central nervous system of the vertebrate.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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Sexually dimorphic development of the mammalian reproductive tract requires Wnt-7a
Article Abstract:
Wnt-7a is a glycoprotein functioning as a signalling molecule in certain developmental contexts. The Wnt-7a associated sterility has been studied in postnatal mice. It was found that the Mullerian duct derivatives of homozygous Wnt-7a mutant females failed to differentiate properly, as compared to wild-type of heterozygous littermates. Wnt-7a-deficient females are infertile due to abnormal oviduct and uterus development, which are Mullerian duct derivatives.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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Vesicles and the spinal chord
Article Abstract:
Proteins of the Hedgehog family are signalling molecules vital for intercellular communication. Vesicle transport and the formation of different types of neuron in the spinal chord are thought to involve Hedgehog signalling.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
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