Retroshuffling the genomic deck
Article Abstract:
Modern genome shapes reflect evolutionary forces, and the exon-shuffling hypothesis suggests that new genes are assembled from parts of old ones. However the way in which these exons are glued together has remained speculative. Moran and colleagues have put forward an unexpected and efficient source of the genomic reshufflings. They considered the abundant L1 (LINE-1) retrotransposons and have shown that L1 can co-mobilize a 3' flanking section of non-L1 DNA to new genomic locations. The read-through transcription of L1 is found to be unusually efficient.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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Yeast retrotransposon revealed
Article Abstract:
The DNA sequence of chromosome III of the yeast Arabidopsis thaliana contains an open reading frame (ORF) near the left telomere. This ORF has now been found to be retrotransposon with the designation Ty5. The telomeric Ty5 insertion is similar to the virus-like retrotransposons and retroviral proviruses and has an internal structure indicating a build-up of mutations. These finding exemplify the progress in genetics research that can be made through analysing the nucleotide sequences in regions between genes.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
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Transcriptional disruption by the L1 retrotransposon and implications for mammalian transcriptomes
Article Abstract:
A human genome model in which L1 has led to numerous subtle but potentially significant transcriptome alterations is proposed. Further the insertion of expression-modulating sequences into host gene introns to reprogram gene expression is presented.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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