Role of NF-kappa-B in p53-mediated programmed cell death
Article Abstract:
It has been possible to gain an insight into the function of the tumour suppressor gene p53. Induction of p53 prompts an activation of NF-kappa-B that correlates with the ability of p53 to induce apoptosis.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
User Contributions:
Comment about this article or add new information about this topic:
Role for the p53 homologue p73 in E2F-1-induced apoptosis
Article Abstract:
Research is presented concerning the activation of a p73 pathway to kill cells through the involvement of transcription factor E2F-1 in the absence of p53.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
User Contributions:
Comment about this article or add new information about this topic:
Regulation of p53 stability by Mdm2
Article Abstract:
An interaction between the p53 tumor-suppressor protein and the Mdm2 oncoprotein is needed to ensure normal cell growth and development. In this process, Mdm2 controls the apoptic functions and cell-cycle arrest in p53. In addition, the enhanced proteasome-dependent degradation created by the interaction results to a reduction in the number of p53 proteins. P53 concentrations in normal cells are thereby reduced.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Role of HIF-1-alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Angiogenesis in cancer and other diseases
- Abstracts: Single cocaine exposure in vivo induces long-term potentiation in dopamine neurons. A critical period for long-term potentiation at thalamocortical synapses
- Abstracts: Northern bobwhite and scaled quail abundance and hunting regulation: a Texas example. Land cover and bobwhite abundance on Oklahoma farms and ranches
- Abstracts: Experimental measurement of the photonic properties of icosahedral quasicrystals. Complete photonic bandgaps in 12-fold symmetric quasicrystals
- Abstracts: Colour takes the field. Hard-core revelations. Backyard exotica