Role of the thrombin receptor in development and evidence for a second receptor
Article Abstract:
The thrombin receptor is important for embryonic development and the cloned receptor is important in fibroblast signalling. A second platelet thrombin receptor is present and different thrombin receptors have different tissue-specific functions. A study reveals that fifty percent of mice whose thrombin receptor gene (tr) is disturbed survive without any bleeding disorders while the rest die. Tr(super -/-) fibroblasts fail to respond to thrombin though tr(super -/-) platelets respond.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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A dual thrombin receptor system for platelet activation
Article Abstract:
Genetic research indicates that gene expression for receptor protease-activated receptor-3 (PAR3) plays a significant role in biochemical thrombin response. Experiments using PAR3-deficient mice are described. Evidence suggests that receptor PAR4 is involved in human platelet function. Platelet activation appears to be triggered by a two-receptor physiological mechanism involving PAR3 and PAR4.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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Thrombin signalling and protease-activated receptors
Article Abstract:
Research is presented concerning the method used by coagulation protease thrombin to regulate the behavior of cells. The role of receptors which are activated by protease is discussed.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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