PAR3 is a cofactor for PAR4 activation by thrombin
Article Abstract:
It has been established that mouse PAR3 is a cofactor for mouse PAR4 cleavage and activation by thrombin. PAR3's cofactor function in mouse platelets indicates that G-protein-coupled receptors can act as accessory molecules that encourage the ligation of other G-protein-coupled receptors.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
User Contributions:
Comment about this article or add new information about this topic:
Role of thrombin signalling in platelets in haemostasis and thrombosis
Article Abstract:
The role of platelets is examined in detail. They have an important function in conditions relating to abnormal clotting, and thrombin signalling is a key factor.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
User Contributions:
Comment about this article or add new information about this topic:
Protease-activated receptor 3 is a second thrombin receptor in humans
Article Abstract:
The coagulation protease thrombin activates leukocytes, platelets, mesenchymal and endothelial cells at sites of vascular damage. They are partially activated by a proteolytically activated G-protein-coupled receptor. A new human thrombin receptor, termed protease-activated receptor 3, has been cloned and characterized. It is expressed in a number of tissues, including mouse megakaryocytes and human bone marrow, making it important in the understanding of thrombin signalling.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: The influence of queen age and quality during queen replacement in honeybee colonies. Perception of the pollen need by foragers in a honeybee colony
- Abstracts: Deficiency of gluataredoxin 5 reveals Fe-S clusters are required for vertebrate haem synthesis. Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter
- Abstracts: Evolution of novel cooperative swarming in the bacterium Myxococcus xanthus. Developmental cheating in the social bacterium Myxococcus xanthus