Runaway telomere elongation caused by telomerase RNA gene mutations
Article Abstract:
The interaction between ribonucleoprotein enzyme telomerase and double-stranded telomeric DNA-binding proteins (DS-TBP) acts to regulate the elongation of chromosomes since telomerase only binds to shrunken telomeres without DS-TBP. However, if an elongated telomere develops mutations, the mutations may disrupt the regulation whether immediately or once too few non-mutated telomeric repeats are present to produce the DS-TBP that inhibits the addition of telomeric DNA to the end of the chromosome.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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Control of telomere growth by interactions of RAP1 with the most distal telomeric repeats
Article Abstract:
Telomeres are specialized DNA-protein structures located at the ends of eukaryotic chromosomes and are responsible for maintaining chromosomal stability and integrity. An analysis of the phenotypic severity of several eukaryotic telomeres revealed that it is directly proportional to the loss of RAP1 binding in mutated telomeric repeats. The results suggest that RAP1 interaction is essential in controlling the length of telomeres.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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Testing telomerase
Article Abstract:
The role of telomerase in human physiology, and its significance in the study of human genetics and inherited diseases are examined in detail.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
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