Export by red blood cells of nitric oxide bioactivity
Article Abstract:
Research is presented concerning the influence of the haemoglobin derived nitric oxide vasoactivity in the release of oxygen from the red blood cells. The ability of red blood cells to dilate the blood vessels is discussed.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
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S-nitrosohaemoglobin: a dynamic activity of blood involved in vascular control
Article Abstract:
S-nitrosohemoglobin (SNO-Hb) may be formed within red blood cells and may help regulate blood pressure and transport of oxygen to tissues. SNO-Hb is formed in the lung as a result of nitrosylation of hemoglobin by oxygen. The extra NO is released during transport in the blood vessels. S-nitrothiols appear to promote the vasoactive effects of SNO-Hb. SNO-Hb(FeII)O2 exhibits moderate NO activity and this characteristic has diagnostic applications.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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Reactions between nitric oxide and haemoglobin under physiological conditions
Article Abstract:
Oxygen instigates the conversion of nitrosylhaemoglobin in the 'tense' T (or partially nitrosylated, deoxy) structure to S-nitrosohaemoglobin in the 'related' R (or ligand-bound, oxy) structure. When oxygen is not present, nitroxyl anion is liberated in a reaction creating methaemoglobin. It has been established that heterolytic cleavage is increasingly favoured over homolytic NO dissociation as the equilibrium position for NO between alpha/beta haems is reached.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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