Slowed recovery of rod photoresponse in mice lacking the GTPase accelerating protein RGS9-1
Article Abstract:
Rod outer segments (ROS) membranes from mice lacking RGS9-1 are found to hydrolyse GTP more slowly than ROS membranes from control mice. Flash responses of RGS9-1- rods increased normally, although recovered more slowly. RGS9-1, possibly combined with Gbeta5-L, is thought to be required for acceleration of hydrolysis of GTP by Galphat.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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Subunits beta-gamma of heterotrimeric G protein activate beta-2 isoform of phospholipase C
Article Abstract:
Important cell responses to hormones and other ligands are often mediated by the versatile G-protein system. The interaction of alpha-subunits of G proteins and a variety of effectors has been shown. Co-transfection assays can be used to show that a complex of the beta- and gamma-subunits of G (G-beta-gamma) specifically activate the beta-1 isoform of phospholipase. These results suggest that different effector pathways through a single receptor may be stimulated by G-alpha and G-beta-gamma subunits.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
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Prolonged photoresponses in transgenic mice rods lacking arrestin
Article Abstract:
Arrestin binding does not seem to be rate limiting for recovery of the rod photoresponse in rods from transgenic mice in which one or both copies of the arrestin gene have been disrupted. When arrestin is not present, the flash response shows a very quick partial recovery. This is followed by a lengthy final phase. It seems that arrestin itself does not play a role in adaptation to background light. In -/- rods, the mechanisms of adaptation seemed to be normal, but they did not adapt normally because the long tails on the elementary responses pushed the response into saturation at very low light intensity.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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