Somatic activation of the K-ras oncogene causes early onset lung cancer in mice

Article Abstract:

Research into ras gene mutations in human tumours is discussed. Adapted 'hit-and-run' gene targeting technology is used to create a new model for mouse strains which are prone to cancer, especially early onset lung cancer.

Models, Innovations, Cancer research, Cancer, Tumors, Letter to the Editor, Genetically modified mice

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Effects of an Rb mutation in the mouse

Article Abstract:

The mutation of the retinoblastoma (RB) tumor-suppressor gene in a strain of mice produced deleterious effects in both heterozygous and homozygous embryos. RB, the best known of the tumor-suppressor genes, has mutations that are associated with several forms of cancer in humans. The heterozygous mice were not vulnerable to retinoblastoma but did produce pituitary tumors deriving from cells lacking the wild-type Rb allele. The homozygous mice were marked by neuronal cell death, abnormal erythropoiesis and death between the 14th and 15th days of gestation.

Health aspects, Mutation (Biology), Mutation, Retinoblastoma

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Restoration of p53 function leads to tumour regression in vivo

Article Abstract:

A Cre-loxP-based strategy is developed for controlling tumour suppressor gene expression in vivo and the restoration of endogenous p53 expression has led to regression of autochthonous lymphomas and sarcomas in mice without affecting normal tissues. The analysis has shown that the tumour regression mechanism depends on the tumour type, where the main consequence of p53 restoration is apoptosis in lymphomas and suppression of cell growth with features of cellular senescence in sarcomas.

United States, Science & research, Gene expression, Lymphomas, Tumour suppressor genes

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