Specific repression of TATA-mediated but not initiator-mediated transcription by wild-type p53
Article Abstract:
The sensitivity of TATA-box-dependent promoters and promoters dependent on initiator elements to p53 repressive effects were examined and compared using two synthetic promoter constructs. In vitro and in vivo experimental results revealed that the activity of promoters using TATA-containing elements was repressed by wild-type p53 expression. This effect, however, was not observed with promoters whose transcription is initiator element-directed. It was suggested that p53 repressed promoter activity repression by direct communication with a basal transcription machinery dependent on a TATA box.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
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A transcription factor controlling development of peripheral sense organs in C. elegans
Article Abstract:
The specification of the neuroblast cell fate requires the lin-32 gene of Caenorhabditis elegans, which encodes the basic-helix-loop-helix (bHLH) protein of the Drosophila achaete-scute family of transcription factors. The similarity of the lin-32 gene's structure and function to that of transcription factors such as bHLH indicates that it must have been present in the primitive ancestral form for the specification of neuronal fate. This confirms that some basic processes of cell-type identification has been conserved during metazoan evolution.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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A eukaryotic transcriptional repressor with carboxypeptidase activity
Article Abstract:
The 3T3 preadipocyte factor AEBP1 is a functional carboxypeptidase (CP) which is responsible for the transcriptional suppression process. AEBP1 may novelly regulate transcription by cleaving other factors involved in transcription. The DNAs encoding AEBP1 were cloned where one clone has a 719-residue open reading frame. A depletion in AEBP1 messenger RNA is observed during adipocyte differentiation.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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