Spliced leader RNAs from lower eukaryotes are trans-spliced in mammalian cells
Article Abstract:
The mechanism by which mammalian cells splice RNA can effect trans-splicing using spliced leader (SL) RNAs. This involves the interaction of a 5' splice site in the SL RNA and a 3' splice site in pre-messenger RNAs. This is established for both in vitro and in vivo mammalian cells. The similarity of of trans-splicing ability by both nematode and mammalian RNA at the 3' sites reveals that the splicing machinery has been conserved between mammals and lower eukaryotes.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
User Contributions:
Comment about this article or add new information about this topic:
Local domains of supercoiling activate a eukaryotic promoter in vivo
Article Abstract:
Linear DNA transcription templates are much less effective than circular templates in Xenopus oocytes. However, circular Xenopus ribosomal RNA transcription templates may be replaced partially by transcription by phage T7 RNA polymerase. This suggests that supercoiled transient domains can fulfill the topological needs of Xenopus rRNA transcription.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
User Contributions:
Comment about this article or add new information about this topic:
The case for an RNA enzyme
Article Abstract:
Issues concerning new evidence on RNA splicing is discussed. Splicing is the reaction that takes place which enables the messenger RNA to become functional.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Site-specific RNase E cleavage of oligonucleotides and inhibition by stem-loops. RNA degradation in Escherichia coli regulated by 3' adenylation and 5' phosphorylation
- Abstracts: Para-aortic splanchnopleura from early mouse embryos contains B1a cell progenitors. Flk1-positive cells derived from embryonic stem cells serve as vascular progenitors
- Abstracts: A matter of time. Centipedes: the great Australian bite. Helmet heads
- Abstracts: Lessons from past climates. Offset of the potential carbon sink from boreal forestation by decreases in surface albedo
- Abstracts: A LEAFY link from outer space. Analysis of 1.9 Mb of contiguous sequence from chromosome 4 of Arabidopsis thaliana