Structural basis for glycosphingolipid transfer specificity

Article Abstract:

The crystal structures of apo-glycolipid transfer protein (GLTP) and lactosylceramide-bound GLTP, in which the bound glycosphingolipid is sandwiched, after adaptive recognition within an unknown two-layer all (alpha)-helical topology is presented. It is seen that GLTP, which has a different architecture from other motifs of lipid-binding and lipid transfer proteins represents a new emerging family of sphingolipid-binding/transfer proteins.

United States, Glycolipids, Protein binding

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Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain

Article Abstract:

The 2.6 A crystal structure of the PAZ domain from human Argonaute eIF2c1 bound to both ends of a 9-mer siRNA-like duplex are reported. PAZ might serve as a silencing pathway, and as an anchoring site for the 3' end of guide RNA within silencing effectors complexes is proposed.

Biological Product (except Diagnostic) Manufacturing, Drugs, Nucleic Acids, Human genetics, RNA

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Recognition of small interfering RNA by a viral suppressor of RNA silencing

Article Abstract:

A conserved biological response to double-stranded RNA that regulates gene expression in plants is called RNA silencing or interference. Viruses produce proteins that suppresses the silencing machinery in order to defend themselves.

Genetic aspects, Plants, Plants (Organisms), RNA interference

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