Sunburnt fission yeast
Article Abstract:
Damaged DNA enters mitosis in all but two cases of mutants, as revealed by the genetic analysis of fission yeast. The mutants of one class prevent undamaged cells from arresting cells in G2, while those of the second class affect the normal functioning of the maturation promoting factor (MPF) by decreasing the minimal size cells must attain to be mitotic, and by destroying damaged DNA's ability to prevent entry into mitosis. The DNA damage in mammalian cells prevents the replication till the damage has been cured, indicating that DNA replication of fission yeast in controlled by gene products.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
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Creative blocks: cell-cycle checkpoints and feedback controls
Article Abstract:
Cells use DNA repair and spindle assembly as feedback controls before the cell division phase of the cell cycle. These feedback controls guarantee that DNA replication, repair and chromosome segregation are completed prior to division by stopping the cell cycle at one of three checkpoints until all three processes are finished. Research indicating that the breakdown of these feedback controls may contribute to carcinogenesis may point the way to more effective anti-cancer treatments.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
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From molecular to modular cell biology
Article Abstract:
Cellular functions are undertaken by modules consisting of many species of interacting molecules. An understanding of the way modules work has relied on a combination of phenomenological analysis and molecular studies. It is likely that general principles governing the structure and behaviour of modules will be discovered with assistance from synthetic sciences, such as engineering and computer science.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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