Switching channels makes sense
Article Abstract:
The development of a stable lipid membrane which can act as an ion gate, opened or closed by the binding of single molecules, represents significant progress towards the development of a device which can follow a trail of single molecules. Gated devices of this kind benefit from the very high flux which takes place as a result of a single molecular interaction. This new device has implications beyond the field of analytical chemistry, especially as single-molecule modulation of a gated event is a key element of biomolecular electronics.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
User Contributions:
Comment about this article or add new information about this topic:
Stochastic sensing of organic analytes by a pore-forming protein containing a molecular adapter
Article Abstract:
It has been established that alpha-, beta- and gamma-cyclodextrins at micromolar concentrations enter the alpha-haemolysin (alpha-HL) channel and produce reversible partial blocks of the ionic current. Beta-cyclodextrin acts as a non-covalent molecular adapter, with the cyclodextrin host acting as a carrier when the residence time of the analyte within the host is quite long. It has been shown that stochastic sensing with adapter molecules is a versatile approach to analyte identification and quantification.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
User Contributions:
Comment about this article or add new information about this topic:
Stochastic sensors inspired by biology
Article Abstract:
It is possible to use engineering membrane probes to produce quick and responsive biosensors with a wide range of potential applications. One of the most significant potential applications may be in pharmaceutical screening using proteomics.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Excited-state enhancement of optical nonlinearities in linear conjugated molecules. Gigantic optical nonlinearity in one-dimensional Mott-Hubbard insulators
- Abstracts: Which histone kinase? Endonucleoytic processing of covalent protein-linked DNA double-strand breaks. Local or global?
- Abstracts: Fungus-growing ants use antibiotic-producing bacteria to control garden parasites. Most smooth closed space curves contain approximate solutions of the n-body problem
- Abstracts: Signs of an early spring. Parental paradoxes. Noble-gas-rich chondrules in an enstatite meteorite
- Abstracts: Magnetic compass and learning of the Y-axis (sea-land) direction in the marine isopod Idotea baltica basteri. Relationship between compass systems of orientation in equatorial sandhoppers