Tense spindles can relax
Article Abstract:
Micromanipulation experiments using grasshopper spermatocytes reveal that chromosome segregation during meiosis involves interaction between chromosomes and microtubules arising from the poles of the spindle. These interactions involve kinetochores that attach to opposite poles of the spindle, directing chromosomal orientation and eventually its segregation. Attachment of the kinetochore is controlled by the tension at the kinetochore, which also regulates spindle-assembly checkpoint and kinetochore moments.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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Guardian spirit blesses meiosis
Article Abstract:
The two copies of a duplicated chromosome ('sister chromatids') need to remain tethered to each other to prevent abnormal chromosome numbers and the chromosome needs to be connected to its opposite number until it is time for their separation. A protein that protects this chromosomal glue is now discovered.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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