The ACE of hearts
Article Abstract:
A deletion polymorphism in the gene that encodes angiotensin converting enzyme (ACE) may increase the risk of cardiovascular disease and myocardial infarction (heart attack). ACE is an important part of the renin-angiotensin system that had previously been linked to hypertension and cardiovascular disease. Francois Cambien and co-workers found that the deletion polymorphism for the ACE gene occurred more often among heart attack patients than among controls. This finding should lead to a broader understanding of the molecular genetics of cardiovascular disease.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
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Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction
Article Abstract:
The DD genotype linked with higher concentrations of circulating angiotensin-converting enzyme (ACE) occurs more often among myocardial infarction patients with low-body mass index and low plasma levels of ApoB than among controls. This indicates that the ACE/ID polymorphism is a powerful risk factor both for myocardial infarction and for coronary heart disease in general. This new risk factor will apply to many people once thought to be in little danger of developing heart problems.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
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The search for new cardiovascular biomarkers
Article Abstract:
The article discusses development of new biomarkers that can be employed for studying the risk factors and prevention measures related to the cardiovascular diseases in humans. High blood pressure, diabetes and smoking are found to be the main factors that lead to such disorders.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2008
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