The oncoprotein Evi-1 represses TGF-beta signalling by inhibiting Smad3
Article Abstract:
A zinc finger protein with possible involvement in leukaemic transformation of haematopoietic cells is encoded by Evi-1. An investigation was undertaken on the effects of Evi-1 on signalling through transforming growth factor-beta (TGF-beta). Evi-1 is shown to repress TGF-beta signalling and antagonize the growth-inhibitory effects, defining a new function of Evi-1 as a signalling repressor through TGF-beta.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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Dishevelled controls cell polarity during Xenopus gastrulation
Article Abstract:
Xenopus dishevelled (Xdsh) is known to play many roles during embryogenesis and its inhibition disrupts convergent extension movements during gastrulation. New research using time-lapse confocal microscopy shows that failure of convergent extension in cells lacking Xdsh is due to defects in cell polarity.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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WNT signalling molecules act in axis formation in the diploblastic metazoan Hydra
Article Abstract:
Research is presented concerning the function of the Wnt/wingless secreted proteins in the long-range organization and short-range inducement of tumorigenesis, organogenesis and axis formation in developing tissues.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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