The subunit story thickens
Article Abstract:
Beta subunits of the heterotrimeric G proteins, in assisting signal transduction across cell membranes, help to link specific receptors to a calcium channel. G proteins, called so because they can bind and hydrolyse guanine nucleotides, consist of alpha, beta and gamma subunits. C. Kleuss and colleagues utilized somatostatin and muscarinic cholinergic receptor-mediated inhibition of Ca2+ currents in rat pituitary GH3 cells and nuclear microinjection of antisense oligonucleotides to determine that these subunits have different roles in coupling receptors to the effector system.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
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Receptor-tyrosine-kinase- and G-beta-gamma-mediated MAP kinase activation by a common signalling pathway
Article Abstract:
Mitogen-activated protein (MAP) kinases can be activated by either G-protein-coupled receptors or tyrosine-kinase receptors, both of which appear to using a common signalling pathways. Shc, Grb2 and Sos become functionally associated through the G-beta-gamma-mediated tyrosine phosphorylation of Shc which occurs before the activation of MAP kinase through Gi-coupled receptors. The blocking of G-beta-gamma-mediated kinase activation by the Shc-Grb2-Sos complex indicates a common pathway of the activation with GPCRs and RTKs.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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Isoprenylation in regulation of signal transduction by G-protein-coupled receptor kinases
Article Abstract:
The isoprenoids, a group of unsaturated lipids, form the molecular basis for the ability of the rhodopsin kinase and beta-adrenergic receptor kinase to begin to deactivate the G-protein-coupled receptors. A 15-C (farnesyl) isoprenoid alters the rhodopsin kinase so that it can commence the deactivation by attaching to photon-activated rhodopsin. Both kinases depend on the isoprenyl moieties to translocate and to be active, showing that the biological regulation of receptors is separate but related.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
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