Tolerance by exhaustion
Article Abstract:
Viruses may escape protective immune response by overwhelming the immune system with their sheer numbers. Under such a situation, the immune system puts up a brief and intense struggle, which eventually leads to exhaustion, deletion of T-lymphocytes and tolerance to the virus. Maintaining the tolerant host alive is advantageous to the virus because the host then becomes a carrier for the rest of its life. This phenomenon has been observed in many animal models, and also in humans exposed to high virus doses.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
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Crucial role of the pre-T-cell receptor alpha gene in development of alpha-beta but not gamma-delta T cells
Article Abstract:
The pre-T cell receptor is necessary for the development of the early thymocytes. The formation of alpha-beta T cells is inhibited in mice lacking the pre-T-cell-receptor alpha gene but the formation of gamma-delta T cells is unaffected. The alpha gene encodes a transmembrane protein which is expressed only in immature T cells.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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Different initiation of pre-TCR and gamma-delta-TCR signalling
Article Abstract:
Research examining the initiation of signalling from the gamma-delta-TCR (T-cell receptor) and pre-TCR using confocal microscopy and biochemistry is presented. There are found to be clear differences between each type.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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