Transformation of axial skeleton due to overexpression of bmi-1 in transgenic mice

Article Abstract:

The bmi-1 gene appears to be involved in the vertebrate Polycomb complex which represses homeotic genes to regulate segmental development during development. While transgenic mice without bmi-1 had posterior transformations of the axial skeleton, transgenic mice overexpressing Bmi-1 protein demonstrate a dose-dependent anterior transformation vertebral identity. The Bmi-1 proteins involvement in homeotic gene suppression is indicated by the shift in the Hoxc-5 anterior expression boundary toward the posterior when Bmi-1 is overexpressed.

Physiological regulation, Biological control systems, Genetically modified mice, Oncogenes

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Requirement for a functional Rb-1 gene in murine development

Article Abstract:

RB-1, a gene the mutation of which has been linked to retinoblastoma, produces different homozygous and heterozygous effects when inactivated in mouse embryos. Heterozygous mice survive to term and exhibit neither physical abnormalities nor the growth of retinoblastoma tumors. On the other hand, homozygous mouse embryos die before birth and exhibit an array of neural and hematopoietic abnormalities.

Abnormalities, Genetic aspects, Nervous system, Developmental genetics, Retinoblastoma, Hematopoietic system, Nervous system abnormalities

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Gene expression in diagnosis

Article Abstract:

Alizadeh and colleagues have examined diffuse large B-cell lymphoma (DLBCL), undertaking gene-expression profiling with a Lymphochip. DLBCL was separated into two categories using clustering analysis, and the gene expression signatures of the subgroups corresponded to certain differentiation stages of B cells.

Gene expression

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