Transient cross-reactive immune responses can orchestrate antigenic variation in malaria
Article Abstract:
The production of a cascade of sequentially dominant antigenic variants due to the short-lived, partially cross-reactive immune responses to parasite-infected erythrocyte surface antigen is described. The mechanism for the maintenance of antigenic variation relying solely on the distinction between two types of immune responses against variant surface antigens (VSAs) is discussed.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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IL-23 promotes tumor incidence and growth
Article Abstract:
A molecular connection between the rise in tumor-associated inflammation and a lack of tumor immune surveillance is shown. The heterodimeric cytokine interluekin (IL-23) increases in human tumors, the expression of which antagonistically regulates local inflammatory responses in tumor microenvironment and infiltration of intra-epithelial lymphocytes.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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Identification of Lps2 as a key transducer of MyD88-independent TIR signalling
Article Abstract:
Research has been conducted on Toll-like receptor which initiates cytokine mediator production and creates inflammatory response. The authors have induced a germline mutation Lps2 via the use of N-ethyl-N-nitrosourea, and have identified Lps2 mutation which is a distal frameshit error in a Toll/interleukin-1 receptor/resistance adaptor protein.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
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