Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis
Article Abstract:
Mutation in a DNA replication factor may explain some deletions and repeating features in the neoplastic regions of sequences in tumour cells. Somatic deletions in poly(dA-dT) sequences and repeats occur in 12% of colorectal carcinoma cells, pointing to a defective replication factor. This reduces replicating fidelity and increases mutation rates in tumor tissues. Similar mutations may be found in other tumor regions in the same patient, leading to a possibility that these are genotypic and phenotypic features and may be diagnosed as an inherited predisposition to carcinoma.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
User Contributions:
Comment about this article or add new information about this topic:
Engagement with transcription
Article Abstract:
Two recent studies on xeroderma pigmentosum (XP-G) present important contributions towards the understanding of repair syndromes. The first study demonstrates the role of the yeast excision repair gene RAD2 in extreme cases of XP-G. The second is an enzymological study showing the similarity between RAD2, XP-G correcting protein and ERCC5 proteins. The relationship between transcription and repair has now been established and could lead to a deeper understanding of human genetics.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
User Contributions:
Comment about this article or add new information about this topic:
Frameshift mutator mutations
Article Abstract:
The frameshift mutations of the microsatellite mutator phenotype (MMP) human tumor cells usually occur in the coding regions hMSH3 and hMSH6. The mutations in these areas are associated with MMP tumors and cancer. The cells possess inactivating mutations in DNA-mismatch repair genes. A progressive mutator mutation model explains the relationship between DNA mismatch repair and MMP cancer, and the temporal associations and hierarchies among mutator genes.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Hydrologically defined niches reveal a basis for species richness in plant communities. Marine species richness
- Abstracts: Climate-induced fluctuations in sea level during non-glacial times. part 2 A balmy Arctic
- Abstracts: Specificity domains distinguish the Ras-related GTPases Ypt1 and Sec4. Ion-channel studies blossom
- Abstracts: Tectonic processes in Papua New Guinea and past productivity in the eastern equatorial Pacific Ocean. Vast Neogene laminated diatom mat deposits from the eastern equatorial Pacific Ocean
- Abstracts: Imaging standing waves in a two-dimensional electron gas. Quantum mirages formed by coherent projection of electronic structure