Uptake of apoptotic cells drives the growth of a pathogenic trypanosome in macrophages
Article Abstract:
Vitronectin receptor engagement by apoptotic cells sparks off PGE2 and transforming growth factor-beta (TGF-beta) release by macrophages. It has been established that the vitronectin receptor is vital, in both apoptotic-cell cytoadherence and the induction of prostaglandin E2/TGF-beta release and ornithine decarboxylase activity in macrophages. The uptake of apoptotic cells reorientates macrophage metabolism towards putrescine production, assisting parasite replication.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
User Contributions:
Comment about this article or add new information about this topic:
Apoptosis of CD8+ T cells is mediated by macrophages through interaction of HIV gp120 with chemokine receptor CDCR4
Article Abstract:
CD8-positive T cells are believed to be important in control of infection by human immunodeficiency virus (HIV) due to their cytotoxic activity. It is reported that the death rate of CD8+ T cells by apoptosis showed marked increase during HIV infection of peripheral blood mononuclear cells in vitro. Apoptosis is mediated by interaction of tumour-necrosis factor-alpha bound to the membrane of macrophages, with a receptor on CD8+ T cells.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
User Contributions:
Comment about this article or add new information about this topic:
Phagocytosis and clearance of apoptotic cells is mediated by MER
Article Abstract:
Research exploring the Mer mediation of apoptotic cells is presented, with relevance to the maintenance of the animal immune systems. It is suggested that the clearance and engulfment of the apoptotic cells is directly related to the Mer receptor.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Detection of magnetic circular dichroism using a transmission electron microscope. Soft equations of state for neutron-star matter ruled out by EXO 0748-676
- Abstracts: Magnetic energy release on the Sun. A 600-day periodicity in solar coronal holes. Scaling of heating rates in solar coronal loops
- Abstracts: Detection of tidal dissipation in the solid Earth by satellite tracking and altimetry. Significant dissipation of tidal energy in the deep ocean inferred from satellite altimeter data
- Abstracts: Nanoscopic channel lattices with controlled anisotropic wetting. Non-destructive determination of local strain with 100-nanometre spatial resolution
- Abstracts: Osmotic generation of 'anomalous' fluid pressures in geological environments. Mechanosensitive channels transduce osmosensitivity in supraoptic neurons