Venter's venture
Article Abstract:
Craig Venter announcement that he could list 95% of the human genes in 18 months is a major breakthrough. Other classic human genome projects expect to finish sometime in the first decade of the next century. Actually, Venter's method merely tags the active genes in particular tissues so that they can be fished out for further analysis, while classic human genome projects aim to map the entire human genome nucleotide sequence. Venter's method could yield immediately useful applications, as in the identification of genes involved in genetic disorders. As such, it can easily attract more funds and potentially dry up funding for the classic human genome projects.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
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Exposing the human nude phenotype
Article Abstract:
There is a human homologue of the nude mouse, which has a congenital absence of hair and a serious immunodeficiency caused by mutations in the winged-helix-nude; Hfh11nu gene. This gene encodes a transcription factor, which is developmentally controlled and directs cell-fate decisions. It has been possible to produce evidence of a human immunodeficiency caused by a gene expressed in specific epithelial cells, rather than in haematopoietic cells. This research provides additional evidence implicating cell-type-specific transcription factors in hair-follicle cycling.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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Complex traits on the map
Article Abstract:
Researchers have mapped a gene responsible for Crohn's disease to a site on chromosome 16 near its centromere. The accomplishment has boosted research on the localization of genes responsible for diseases having complex traits. The researchers genotyped family members for 270 highly polymorphic markers proliferating the genome. They used multipoint affected sibpair analysis to localize complex trait loci.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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