Visualization of transient encounter complexes in protein-protein association
Article Abstract:
Paramagnetic relaxation enhancement was used to demonstrate the existence and visualize the distribution of an ensemble of transient, non-specific encounter complexes under equilibrium conditions for a relatively weak protein-protein complex between the amino-terminal domain of enzyme I and the phosphocarrier protein HPr. Restrained rigid-body simulated annealing refinement against the paramagnetic relaxation enhancement data enables to obtain an atomic probability distribution map of the non-specific encounter complex ensemble that qualitatively correlates with the electrostatic surface potentials on the interacting proteins.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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Life as we know it
Article Abstract:
The article focuses on segments of 'ultraconserved' DNA-sections that have stayed exactly same throughout recent vertebrate evolution and they are identical in humans, rats and mice.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
User Contributions:
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