p53, guardian of the genome
Article Abstract:
The protein p53's role in protecting against cancer has been made clearer thanks to the efforts of three research groups. Momand and colleagues found the rat protein that co-immunoprecipitates with p53 as the rat homologue of the mouse MDM2 protein. Oliner and colleagues then found the human homologue of MDM2 and mapped it to the human chromosome 12, which was also capable of binding p53. Moreover, 17 of 42 human sarcomas revealed gene amplification of the MDM2 locus. Lastly, Farmer and colleagues demonstrated that the transcriptional activation of p53 can be determined in vitro.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
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A death in the life of p53
Article Abstract:
Recent research findings have established the p53 gene as a crucial element in the induction of apoptosis through radiation and chemotherapeutic DNA-damaging drugs. By proving that a tumor suppressor gene is involved in the induction of programmed cell death, two fields in cancer research have been brought together. It is only with this discovery that a molecular description of programmed cell death has been achieved. Programmed cell death occurs in multicellular organisms and is vital in organogenesis, tissue homeostasis and removal of autoreactive clones in the immune system.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
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Checkpoint policing by p53
Article Abstract:
The suggestion that the tumor-suppressor protein p53 is essential to the physiological response to DNA damage is not supported by experimental research. Other factors are known to influence sensitivity to alkylating agents, nor do primary and SV40-transformed cells show the variation in sensitivity to ionizing radiation that should occur if this hypothesis were true. The rebuttal view is that although other checkpoints besides p53 undoubtedly do exist, the inactivation of the p53 pathway is nevertheless essential to limiting the growth of neoplasia.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
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